Wednesday, March 14, 2018

Thanks to a recent discovery about a drug called Tideglusib developed for and trialled to treat Alzheimer’s disease was discovered that Tideglusib happens to promote the natural tooth regrowth mechanism allowing the tooth to repair cavities.

A new discovery about a drug developed for Alzheimer's patients might replace fillings for cavity repair. Tideglusib stimulates stem cells in the pulp of teeth, promoting new dentine production and natural tooth repair.

Goodbye, Fillings

Dental fillings may soon be left in the ash heap of history, thanks to a recent discovery about a drug called Tideglusib. Developed for and trialled to treat Alzheimer’s disease, the drug also happens to promote the natural tooth regrowth mechanism, allowing the tooth to repair cavities.
Tideglusib works by stimulating stem cells in the pulp of teeth, the source of new dentine. Dentine is the mineralized substance beneath tooth enamel that gets eaten away by tooth decay.
Teeth can naturally regenerate dentine without assistance, but only under certain circumstances. The pulp must be exposed through infection (such as decay) or trauma to prompt the manufacture of dentine. But even then, the tooth can only regrow a very thin layer naturally—not enough to repair cavities caused by decay, which are generally deep. Tideglusib changes this outcome because it turns off the GSK-3 enzyme, which stops dentine from forming.
Image Credit: ales_kartal/Pixabay
Image Credit: ales_kartal/Pixabay
In the research, the team inserted small, biodegradable sponges made of collagen soaked in Tideglusib into cavities. The sponges triggered dentine growth and within six weeks, the damage was repaired. The collagen structure of the sponges melted away, leaving only the intact tooth.
Thus far, the procedure has only been used in mouse teeth. Yet as King’s College London Dental Institute Professor and lead author Paul Sharpe told The Telegraph, “Using a drug that has already been tested in clinical trials for Alzheimer’s disease provides a real opportunity to get this dental treatment quickly into clinics.”
He added, “The simplicity of our approach makes it ideal as a clinical dental product for the natural treatment of large cavities, by providing both pulp protection and restoring dentine.”

Thursday, October 5, 2017

Link between depression medication and bruxism (grinding teeth)

I felt my patient could get a deeper understanding of the correlation of SSRI (serotonin reuptake inhibitor drugs and Bruxism) by reading this very interesting article from Dr Spear's website.

It is very important to understand that these type of antidepressant drugs can cause involuntary muscle contractions that can lead to grinding causing cracked, fractures teeth, restorations and even loss of teeth.

Link Between Medications and Bruxism?

Link Between Medications and Bruxis

By Jeff Lineberry on June 15, 2017 | 4 comments Print

In today’s world, everyone is being pushed to their limits in just about every aspect that you can imagine. More is demanded with fewer resources and less time. All this becomes a source of stress and anxiety and even depression for the population as a whole.

This “epidemic” of depression and anxiety spurred the development of newer medications with fewer side effects to help manage these conditions and hence, the SSRIs (selective serotonin reuptake inhibitors) were born in 1988. Since then, recent reports show that the use of the SSRIs (i.e. Paxil, Zoloft, Prozac, Celexa, Effexor, etc.) has increased more than 400 percent!

As dentists, we see on a regular basis the signs of bruxism or clenching/grinding of the teeth, and some of it is the result of stress and anxiety. But another factor that we have to keep in mind is that patients are now taking more anti-anxiety and antidepressants than ever before in history. It is often overlooked, but the SSRIs and even some of the SSNRIs (Selective Serotonin Norepinephrine Reuptake Inhibitors) often increase bruxism or clenching and grinding effects at night.

This leads to patients having an increased frequency of headaches, jaw pain and other symptoms of clenching/grinding. In my own practice, I have seen many patients that have presented with increased frequency and intensity of symptoms shortly after the patient starts on these medications. I have found that sometimes a change in medication or reduction in the dosage with the help of the prescribing medical doctor can help, but sometimes there seems to be little to no effect.

In recent studies, there is support for a theory of how these medications cause an imbalance in the brain, leading to a drug-induced bruxism that sometimes does not go away with a decrease or cessation of the medication and may even require other medications to help alleviate the bruxism.1

So the next time you see patients on one of these medications you might want to keep this in mind, as the bruxism will cause your dentistry to fail quicker and may be causing your patients a lot more issues.


1. Milanlıoglu, A. (2012). Paroxetine-induced severe sleep bruxism successfully treated with buspironeClinics67(2), 191–192.
Jeff Lineberry, D.D.S., F.A.G.D., FICOI, Accredited Member-AACD, Spear Visiting Faculty, and Contributi

Thursday, August 10, 2017